While our laboratory is currently still closed, we are working relentlessly to be able to offer you special innovations in the near future. 

Among several other things, we are pleased to announce that our lab will be working with state-of-the-art analyzers to provide deeper and more precise insights into your patients' mitochondrial health and cell metabolism. With the Seahorse XF PRO Analyzer from Agilent and the MACSQuant Analyzer 10 from Miltenyi, we offer you innovative measurements that can provide valuable information for the diagnosis and therapy of various diseases.

Our new analysis capabilities and their advantages for you:

1. Analyze mitochondrial numbers in resting and activated immune cells
   Immune cells are dependent on energy for an effective immune response. With our new devices, we can specifically measure mitochondrial numbers in both resting and activated immune cells. This data helps to clarify whether the cells have sufficient energy for normal function, especially in patients with autoimmune or inflammatory diseases. An imbalance in the number of mitochondria can indicate impaired energy production, which can lead to an inadequate immune response.

   Advantage for you and your patients: This analysis makes it possible to identify disorders in the immune system at an early stage. You can better assess the function of your patients' immune cells at a cellular level and take targeted therapeutic measures to strengthen or correct immune functions. This is particularly relevant for chronic inflammation, autoimmune diseases or immunocompromised patients.

2. Mitochondrial number in living cells to investigate mitochondrial diseases
   Our analyses enable us to precisely measure the mitochondrial number in living cells, which provides crucial insights into diseases associated with impaired mitochondrial function and energy deficiency. Impaired mitochondrial function is often a key factor in neurodegenerative diseases, muscle diseases and metabolic disorders in particular. These measurements offer us a direct opportunity to investigate the role of mitochondria in disease progression. 

   Advantage for you and your patients: This method provides a direct analysis of cellular energy production and allows you to react early to disturbances in mitochondrial function. This allows you to pursue targeted therapeutic approaches aimed at improving cellular energy and thus significantly improve your patients' quality of life.

3. Simultaneous real-time measurements of oxygen consumption rate (OCR), proton efflux rate (PER) and extracellular acidification rate (ECAR)
   With the Seahorse XF PRO Analyzer, we can measure in real time important cellular functions such as oxygen consumption rate (OCR) to assess mitochondrial respiration, proton efflux rate (PER) and extracellular acidification rate (ECAR), which are critical for glycolysis and overall metabolic activity of cells. These simultaneous measurements provide us with a comprehensive picture of the balance between mitochondrial respiration and glycolysis - key metabolic pathways that play a role in the development of many diseases, including cardiovascular disease, cancer and metabolic disorders. 

   Benefit for you and your patients: By measuring these parameters simultaneously, you gain a holistic view of cell metabolism and can specifically investigate whether and to what extent these processes are disturbed in your patients. This gives you the opportunity to choose the optimal treatment, be it through dietary changes, drug interventions or other therapeutic measures aimed at improving cellular energy regulation.

4. Label-free analytical detections for the assessment of cellular metabolic function
   With our new technologies, we can perform label-free detections to analyze cellular metabolism in cultured cells and ex vivo samples. This allows us to evaluate cellular functions in their natural environment without affecting the cells with dyes or other markers. This is particularly advantageous for complex tissues or sensitive cell types, as we obtain an unadulterated picture of cell function. 

   Advantage for you and your patients: This gentle analysis method ensures more precise and reliable results, as the cell functions are not distorted by external markers. This enables a clearer and more reliable assessment of metabolic function and helps to avoid misinterpretations. It can be particularly helpful in the investigation of complex disease patterns associated with defective metabolic processes. 

We look forward to being able to offer you even more precise diagnostics and optimized therapeutic approaches for your patients with these expanded analysis capabilities.

Yours sincerely,
Your IGL Laboratory Team

Dear customers, dear medical professionals,

As we have already had to inform you, our highly esteemed managing partner, boss, friend and mentor passed away on the morning of 27 July 2024 after a long, serious illness.

As we would like to continue and further develop his life's work in his spirit and with his vision, we are working on a complete reorganisation of the IGL Laboratory for Holistic Diagnostics.

As a result, we will no longer be offering any of the analyses we previously carried out.

Instead, however, we would like to offer you particularly innovative and established analysis options for cellular energy management in the near future.

With our new methods, we will be able to visualise the diverse and complex functioning and health of the mitochondria, providing you with new diagnoses and treatment options.

In order to be able to offer you these innovations and use our resources for the reorientation as optimally as possible, our laboratory is expected to remain closed until 15 October 2024.

We will inform you of the exact date of our reopening in due course.

We look forward to being your trusted and reliable partner again in the near future to support you in your clinical activities.

We thank you for your loyalty and patience so far.

Yours sincerely

Your IGL team

Dear customers, dear medical professionals,

we are deeply saddened to announce that our esteemed managing partner, boss, friend and mentor

Stefan Georgios Moellhausen

passed away in peace and without pain on the morning of July 27, 2024 after a long, difficult illness that he endured with great patience.

We bid farewell with great gratitude and will continue and further develop his life's work in his spirit and with his visions.

Your IGL Laboratory Team